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KMID : 0608619960060020067
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Korean Journal of Aerospace and Environmental Medicine
1996 Volume.6 No. 2 p.67 ~ p.81
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A Follow up Study on the Change of Rabbit EKG by Hyperbaric Oxygenation in Acute Carbon Monoxide Poisoning
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김영렬
이수진/송재철/최보율/김정현/이용호/박항배
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Abstract
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Reoxygenation of a previously hypoxic heart results in significant myocardial damage rather than improvement through the mechanism termed "oxygen paradox". Xanthine oxidase (XO) activity is a major potential source of superoxide radical, and it
has
been
proposed that free radical production, particularly by XO, plays an important role in the genesis of reperfusion injury of myocardium. Hyperbaric oxygen (HBO) therapy is considered to be the treatment of choice for carbon monoxide (CO) poisoning.
But
instead of improving cardiac function, reoxygenation during HBO therapy may result in myocardial damage.
The major objective for this investigation was to test the hypothesis oxygen paradox may be produce myocardial damage during HBO treatment in acute CO poisoning and to confirm whether allopurinol, a XO inhibitor, protect myocardial injury in
rabbit
heart.
As a pretreatment, rabbits were exposed to CO of 4,000 ppm for 1 hour and then exposed to HBO of ATA for 2 hours. Eleven rabbits rabbits were treated with allopurinol(50mg/kg) before study and exposed in the same way as above.
@ES The results are summarized as follows
@EN 1. The effects of CO poisoning observed in EDG were improved by normal ambient air (AA) respiration, No deleterious changes were found in CO-AA group even after certain ammount of exposure time under Aa, which suggests that there was no
oxygen
paradox after CO poisoning.
2. Myocardial injury increased significantly after HBO in CO-HBO group supporting the hypothesis of "oxygen paradox" in "Co-HBO" model.
3. The myocardial injury did not decrease in rabbits treated with allopurinol. This result suggests that the different mechanism is involved in CO-HBO model
therefor in order to detect the myocardial damage of HBO therapy in CO poisoning contionuous EKG monitoring will be necessary during and after HBO therapy and to investigate mechanism of damage more research is needed to analyze the XO activity
and
superoxide radical in oxygen paradox which were not included in this study.
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KEYWORD
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